I have a Xenogears ISO, and when I ran it (I mount all my ISOs with Alcohol 120%), it ran soundless. When I closed it down to muck with sound settings, it would not run. So I reset them, and it still wouldn't work. Now, the only thing that works (I tried Star Ocean Second Story (worked perfectly before, nothing now), Suikoden II (nothing), and Tactics Ogre: LUCT (ran the Atlus corporate logo slowly, sputtering, and soundless once, then stopped working)) is the BIOS, which has sound and works fine.
I'm running a 1.73GHz dual-core Toshiba Satellite with an integrated Intel GFX chipset...
I have ePSXe 1.6.0, with Pete's graphics plugins, using DX6 D3D 1.76 and the PeOpS sound plugin 1.09, which does not "test" (as in the button) as working properly, along with the ePSXe sound core. My settings are below in screenshots:
The top two sound settings of the four are selected, the fourth will not stay selected, the third sometimes does.
No subchannel options configured on the CDROM plugin, which is the ePSXe core.