There are so many methods/alternatives to creating ISO's, it's ridiculous.
My most comfy means would be to use Alcohol 120%, using the 'Playstation' setting, as well as making it a .ccd (CloneCD) extension, rather than a .mdf/s extension.
r2rX
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ready2rumbelX
-Intel Core 2 Quad Q6600 (@3200Mhz)
-Gigabyte 965P-S3 motherboard
-2x2GB G.Skill PC-6400 (DDR2 800Mhz) RAM (4-4-4-12)
-Seagate 320GB (IDE) and Western Digital 500GB (SATA II) H.D
-Sapphire Radeon HD 4870 512MB GDDR 5 (850/4600)
-Windows Vista Ultimate SP1 (x64)
-Realtek HD w/ Creative PC Works 5.1
-2 x L.G DVD/CD-RW Combo - GSA-H62N