To be honest, I actually experienced what you people are talking about now. It just happened one day and I couldn't access anything on my secondary drive and it was slow on my primary drive. I don't think I did anything special to cause it either.
/me points finger at microsoft
__________________
AMD Athlon64 X2 4400+ Toledo, Nvidia GeForce 7950GT SLi, 2GB PC3200 2-3-2-5, ABit AN8-SLi, Sound Blaster X-FI XtremeMusic