Disabling "SPU IRQ Hack" in ePSXe sound config should correct this. DO NOT disable it inside the plugin config(actually, you can disable it in the plugin, but then you have to enable it in the sound config. As far as one of them is enabled and the other is disabled, the stuttering sound in MDECs should not occur).
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But there is someone who remembers you
Someone waiting for a sign that leads the way to you
There is someone who will die for you
Keep that in mind when the hope fails