[euphoria]

Everyone who play MGS should use Null's SPU and try those 'buffer length' settings. I play MGS with 'buffer length' set to 125 and 'block' to 10. And i know that it says 'please enter value between 1-100' but it still uses and saves that 125 - and it makes difference.
I have a Duron 700, voodoo1, SB vibra 128, 128mb mem and use ISO. The sound skips occasionaly but not as far often as with every other SPU. I think that good buffer length depends on your machine specs.

But there are problems other than that:
MGS crashes at least in 3 places using ePSXe v.1.20(all crash after the non-interactive scenes):
-Snake talks to Pres. Baker
-Snake talks to DARPA chief
-Snake talks to Hal Emmerich
Use 1.01 on these parts.

And at least on my computer, long 'videos' tends to leave subtitles behind the sound&graphics and end too early. My graph card has a little impact on that too.