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Most if not all of these virtualization solution lack gpu acceleration, so DX10, I really dont think would be manageable, if even DX9 is being troublesome. Such apps are handier with programs and for crossplatform testing, not really for gaming.
The overhead is generally pretty big (in VMware for instance), but Virtualbox is much more lenient on system ressources, and yet managing to remain nearly as capable as VMware...
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