Personally, i'd recommend ESET Smart Security and Spybot - Search and Destroy. There hasn't been a single problem occuring (whether on XP or Vista) since sticking with this combination.
I had tried Kaspersky a while ago....not a fan of it.
Norton....I haven't used it since it was bloat-ware AGES ago....I don't know how it is today.
McAfee...had used it for a decent period of time prior to encountering ESET NOD32/Smart Security...
r2rX 
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ready2rumbelX
-Intel Core 2 Quad (@3200Mhz)
-Gigabyte 965P-S3 motherboard
-2GB TwinMOS PC-6400 (DDR2 800) RAM
-Seagate 80GB and 320GB 7200rpm H.D
-nVidia GeForce 7900GS 256MB DDR III (610/1560)
-Windows Vista Ultimate SP1 (x86)
-Realtek HD w/ Creative PC Works 5.1
-2 x L.G DVD/CD-RW Combo - GSA-H62N
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