I ran Vista Ultimate for about a week, but it had a few things about it that really bugged me. The new breadcrumb explorer is annoying. The way line-in and other audio channels can't be manually controlled, etc.. Not to mention that even with my rather decent CPU and amount of RAM, it was extremely sluggish at times, even when I wasn't doing anything. All in all, I think I'll wait until it gets some better drivers and maybe a service pack to work out some of the issues.
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Intel Core i7 920 @ 3.4 Ghz | 6 GB DDR3 RAM in Triple Channel | GeForce GTX 285
2.5 TB Hard Drive Space | Windows 7 Ultimate x64
Official betatester of PCSX2 and Co-owner of General Emulation