@Fuzzums: I'm pretty sure that a graphic-display engine can't be compatible or incompatible with a game within an emulator. So you're safe on that. Under sound configuration, do you have all three of the first three options checked (Sound, CDDA Sound, and XA Sound)? And have you tried checking/unchecking the fourth option? Playing with the sound plugin options is the key here.
It's been reported here and there that the game will not play properly from disk, and that it needs to be either directly loaded or mounted to a virtual drive. Not everybody has had that problem, but those who did reported similar problems with audio loss.